Phenotypes associated with this allele

• Allele Symbol: Aatk^tm1Shhi
• Allele Name: targeted mutation 1, Shin-ichi Hisanaga
• Allele ID: MGI:5428170
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aatk^tm1Shhi/Aatk^tm1Shhi	involves: C57BL/6J	MGI:5428192

Genotype
MGI:5428192

hm1

• Allelic Composition: Aatk^tm1Shhi/Aatk^tm1Shhi
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain size ( J:184851 )

• slightly

abnormal neurite morphology ( J:184851 )

• reduced number of neurites

abnormal axon morphology ( J:184851 )

• longer than in wild-type neurons

• increased Rab11a+ vesicles with more dynamic endosome recycling compared to in wild-type neurons

• however, over-expression of Aatk rescues phenotype

abnormal axonal transport ( J:184851 )

• faster endosome mean velocity than in wild-type neurons