Lat2^tm3.1Wz
Targeted Allele Detail

Summary

• Symbol: Lat2^tm3.1Wz
• Name: linker for activation of T cells family, member 2; targeted mutation 3.1, Weiguo Zhang
• MGI ID: MGI:5316132
• Synonyms: LAB^m
• Gene: Lat2 Location: Chr5:134628876-134643879 bp, - strand Genetic Position: Chr5, 74.7 cM
• Alliance: Lat2^tm3.1Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181866
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exons 7 through 12 were replaced with the corresponding sequence with nucleotide substitutions that result in the amino acid substitution of phenylalanine for tyrosine at positions 98, 121, 139, 160 and 192. A floxed neo cassette was inserted downstream of exon 6 and removed by cre-mediated recombination. (J:181866)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat2 Mutation: 19 strains or lines available

References

• Original: J:181866 Zhu M, et al., Tyrosine Phosphorylation-Independent Regulation of Lipopolysaccharide-Mediated Response by the Transmembrane Adaptor Protein LAB. J Immunol. 2012 Mar 15;188(6):2733-41
• All: 1 reference(s)