Phenotypes associated with this allele

• Allele Symbol: Lat2^tm3.1Wz
• Allele Name: targeted mutation 3.1, Weiguo Zhang
• Allele ID: MGI:5316132
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lat2^tm3.1Wz/Lat2^tm3.1Wz	B6.Cg-Lat2^tm3.1Wz	MGI:5316282

Genotype
MGI:5316282

hm1

• Allelic Composition: Lat2^tm3.1Wz/Lat2^tm3.1Wz
• Genetic Background: B6.Cg-Lat2^tm3.1Wz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:181866 )

N • LPS-treated mice and LPS-stimulated dendritic cells exhibit normal IL10 and IL12 production

increased mast cell degranulation ( J:181866 )

• mediated by Fc RI with increased calcium flux

enlarged spleen ( J:181866 )

increased memory T cell number ( J:181866 )

• higher percentage of activated/memory T cells compared to in wild-type mice

abnormal T cell physiology ( J:181866 )

• T cells stimulated with anti-CD3 in the presence of IL2, rested and re-stimulated with anti-CD3 and anti-CD8 exhibit enhanced calcium flux compared with similarly treated wild-type cells

increased interferon-gamma secretion ( J:181866 )

• from CD8+ T cells stimulated with anti-CD3 in the presence of IL2, rested and re-stimulated with anti-CD3 and anti-CD8

increased susceptibility to endotoxin shock ( J:181866 )

• mice are hyperresponsive to LPS-induced septic shock with increased serum levels of TNF compared with wild-type mice

• however, lethality in response to LPS is normal

hematopoietic system

increased mast cell degranulation ( J:181866 )

• mediated by Fc RI with increased calcium flux

enlarged spleen ( J:181866 )

increased memory T cell number ( J:181866 )

• higher percentage of activated/memory T cells compared to in wild-type mice

abnormal T cell physiology ( J:181866 )

• T cells stimulated with anti-CD3 in the presence of IL2, rested and re-stimulated with anti-CD3 and anti-CD8 exhibit enhanced calcium flux compared with similarly treated wild-type cells

growth/size/body

enlarged spleen ( J:181866 )

cellular

increased mast cell degranulation ( J:181866 )

• mediated by Fc RI with increased calcium flux