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Targeted Allele Detail
Symbol: Panx1tm1.1Fama
Name: pannexin 1; targeted mutation 1.1, Fabio Mammano
MGI ID: MGI:5297171
Synonyms: Panx1tm1Mony
Gene: Panx1  Location: Chr9:15005785-15045478 bp, - strand  Genetic Position: Chr9, 4.52 cM
Panx1tm1.1Fama/Panx1tm1.1Fama Panx2tm1.1Mony/Panx2tm1.1Mony mice are protected in a stroke model

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:178055
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ gene and floxed neo cassette was inserted into exon 1. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by quantitative RT-PCR on hippocampus extracts. (J:177671, J:178055)
Generation of the Panx1tm1.1Fama allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Panx1 Mutation:  4 strains or lines available
Original:  J:178055 Anselmi F, et al., ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18770-5
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory