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Panx1tm1.1Fama
Targeted Allele Detail
Nomenclature
Symbol: Panx1tm1.1Fama
Name: pannexin 1; targeted mutation 1.1, Fabio Mammano
MGI ID: MGI:5297171
Synonyms: Panx1tm1Mony
Gene: Panx1  Location: Chr9:15005785-15045478 bp, - strand  Genetic Position: Chr9, 4.52 cM
Panx1tm1.1Fama/Panx1tm1.1Fama Panx2tm1.1Mony/Panx2tm1.1Mony mice are protected in a stroke model

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178055
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ gene and floxed neo cassette was inserted into exon 1. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by quantitative RT-PCR on hippocampus extracts. (J:177671, J:178055)
Generation of the Panx1tm1.1Fama allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Panx1 Mutation:  4 strains or lines available
References
Original:  J:178055 Anselmi F, et al., ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18770-5
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory