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Phenotype Image Detail
Image
Caption (I) Focal cerebral ischemia was induced by occlusion of the middle cerebral artery. Double deletion of both Panx1tm1.1Fama/Panx1tm1.1Fama (Px1-/-) and Panx2tm1.1Mony/Panx2tm1.1Mony (Px2-/-) significantly reduced the infarct volume compared with wild-type mice (Px1+/+ Px2+/+) littermates. **P < 0.01 (t test, n = 6-10).
Copyright This image is from Bargiotas P, Proc Natl Acad Sci U S A 2011 Dec 20;108(51):20772-7. Copyright 2011 National Academy of Sciences, U.S.A. J:180516
Associated
Alleles
Symbol Name
Panx1tm1.1Fama pannexin 1; targeted mutation 1.1, Fabio Mammano
Panx2tm1.1Mony pannexin 2; targeted mutation 1.1, Hannah Monyer
Associated
Genotypes
Allelic Composition Genetic Background
Panx1tm1.1Fama/Panx1tm1.1Fama
Panx2tm1.1Mony/Panx2tm1.1Mony 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory