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Gt(ROSA)26Sortm1Mgn
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1Mgn
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Mark A Magnuson
MGI ID: MGI:5085305
Synonyms: ROSA26LCA
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Unknown
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
  Gt(ROSA)26Sortm1Mgn involves 1 genes/genome features (Setd5) View all
 
Mutation detailsA ~5-kb segment of the gene including the promoter and first exon has been replaced by a lox71/lox2272-flanked pair of selection cassettes encoding a puromycin N-acetyltransferase/truncated HSV1 thymidine kinase fusion protein and neomycin phosphotransferae, respectively expressed under control of the mouse phosphoglycerate kinase promoter and the synthetic bacterial EM7 promoter (Pgk-puro/tk and EM7-neo). (J:174255)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  741 strains or lines available
Notes
References
Original:  J:174255 Chen SX, et al., Quantification of factors influencing fluorescent protein expression using RMCE to generate an allelic series in the ROSA26 locus in mice. Dis Model Mech. 2011 Jul-Aug;4(4):537-47
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory