Tg(CD2-Fyn/Lck)3Rza
Transgene Detail

Summary

• Symbol: Tg(CD2-Fyn/Lck)3Rza
• Name: transgene insertion 3, Rose Zamoyska
• MGI ID: MGI:4946119
• Synonyms: FU-Lck^tg
• Transgene: Tg(CD2-Fyn/Lck)3Rza Location: unknown
• Alliance: Tg(CD2-Fyn/Lck)3Rza page

Transgene origin

• Strain of Origin: (CBA x C57BL/10)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Fyn/Lck)3Rza expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fyn (MGI:95602)	Transgene codes for a fusion protein of Fyn and Lck.
  mouse	Lck (MGI:96756)	Transgene codes for a fusion protein of Fyn and Lck.

• Mutation details: The transgene expresses a cDNA encoding a fusion protein constructed from the Fyn unique domain (aa 1-85) with the Lck SH3, SH2 and kinase domains, under the control of the human CD2 promoter. A C-terminal V5 epitope tag was added to the construct. (J:168430)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CD2-Fyn/Lck)3Rza

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:168430 Salmond RJ, et al., Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas. Blood. 2011 Jan 6;117(1):108-17
• All: 1 reference(s)