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S1pr2tm1Ytak
Targeted Allele Detail
Summary
Symbol: S1pr2tm1Ytak
Name: sphingosine-1-phosphate receptor 2; targeted mutation 1, Yoh Takuwa
MGI ID: MGI:4881823
Gene: S1pr2  Location: Chr9:20877248-20888089 bp, - strand  Genetic Position: Chr9, 7.68 cM
Alliance: S1pr2tm1Ytak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168060
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding exon was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on uterus, testis, kidney, spleen, liver, lung, heart, and brain extracts. (J:168060)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr2 Mutation:  45 strains or lines available
References
Original:  J:168060 Du W, et al., S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Cancer Res. 2010 Jan 15;70(2):772-81
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory