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Targeted Allele Detail
Symbol: Magel2tm1.1Mus
Name: melanoma antigen, family L, 2; targeted mutation 1.1, Francoise Muscatelli
MGI ID: MGI:4849506
Gene: Magel2  Location: Chr7:62377010-62381640 bp, + strand  Genetic Position: Chr7, 34.37 cM
Germline Transmission:  Earliest citation of germline transmission: J:166548
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe 5' portion of the coding region was replaced with a floxed hygro cassette. Cre-mediated recombination removed the hygro cassette. The absence of expression in the brain was confirmed by immunohistochemistry. (J:166548)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Magel2 Mutation:  30 strains or lines available
Magel2 is only expressed paternally (imprinted maternally).
Original:  J:166548 Schaller F, et al., A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene. Hum Mol Genet. 2010 Dec 15;19(24):4895-905
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
The Jackson Laboratory