Analysis Tools
mortality/aging
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• when this allele is inherited paternally, half of expected mice survive to P1
• however, lethality can be rescued by injection of oxytocin
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behavior/neurological
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• when this allele is inherited paternally
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• when this allele is inherited paternally, more mice exhibit weak suckling activity compared with wild-type mice
• however, suckling activity can be rescued by injection of oxytocin
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nervous system
| N |
• brain morphology is normal
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• when this allele is inherited paternally, hypothalamic levels of amidated neuropeptides (oxytocin, arginine-vasopressin, and orexin-A) compared with wild-type mice
• when this allele is inherited paternally, maturation of oxytocin in the hypothalamus is impaired and intermediate forms accumulate compared to in wild-type mice
• however, mice exhibit normal hypothalamic levels of adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone and pituitary levels of oxytocin, arginine-vasopressin, and orexin-A
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homeostasis/metabolism
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• 12 hours after birth when this allele is inherited paternally
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growth/size/body
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• between P0 and P3 when this allele is inherited paternally
• however, weight between P3 and P4 is normal and only tends to be lower until weaning
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