Rad50tm2.1Flv
Targeted Allele Detail
|
Symbol: |
Rad50tm2.1Flv |
Name: |
RAD50 double strand break repair protein; targeted mutation 2.1, Richard A Flavell |
MGI ID: |
MGI:4837633 |
Synonyms: |
RHS457, RHS4,5,7- |
Gene: |
Rad50 Location: Chr11:53540346-53598146 bp, - strand Genetic Position: Chr11, 31.98 cM, cytoband A5-B1
|
Alliance: |
Rad50tm2.1Flv page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:165055
|
Parent Cell Line: |
TC1/TC-1 (ES Cell)
|
Strain of Origin: |
129S6/SvEvTac
|
|
Allele Type: |
|
Targeted |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: In ES cells containing Rad50tm1Flv, which lacks DNaseI hypersensitive site 7 (RHS7), floxed neo cassette replaces DNaseI hypersensitive site 4 and 5 (RHS4,5) between exon 21 and exon 22. Cre mediated recombination removed the neo cassette leaving the remaining DNaseI hypersensitive site 6 (RHS6) in intron 21 and exons 22 through 24 floxed. Western blot analysis confirmed normal protein expression.
(J:165055, J:196154)
|
|
Generation of the Rad50tm2.1Flv allele |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Rad50 Mutation: |
53 strains or lines available
|
|
Original: |
J:165055 Koh BH, et al., Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10614-9 |
All: |
2 reference(s) |
|