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Gt(ROSA)26Sortm1(NOTCH3)Sat
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(NOTCH3)Sat
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Spyros Artavanis-Tsakonas
MGI ID: MGI:4830990
Synonyms: WT76
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133358
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(NOTCH3)Sat expresses 1 gene
 
Mutation detailsA targeting vector containing a splice acceptor site, a loxP-flanked PGK neomycin cassette, a human NOTCH3 cDNA and an IRES-nuclear GFP sequence was inserted into the GT(ROSA)26Sor locus. (J:133358)
Schematic of the Gt(ROSA)26Sortm1(NOTCH3)Sat, Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat and Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat constructs
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  715 strains or lines available
References
Original:  J:133358 Arboleda-Velasquez JF, et al., Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4856-61
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory