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Arhgef4tm1Taki
Targeted Allele Detail
Nomenclature
Symbol: Arhgef4tm1Taki
Name: Rho guanine nucleotide exchange factor (GEF) 4; targeted mutation 1, Tetsu Akiyama
MGI ID: MGI:4453566
Synonyms: Asef-
Gene: Arhgef4  Location: Chr1:34678188-34813309 bp, + strand  Genetic Position: Chr1, 13.34 cM
Impaired endothelial cell sprouting from Arhgef4tm1Taki/Arhgef4tm1Taki aortas

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159959
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neo cassette was inserted into exon 2. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:159959)
Targeted disruption of the Arhgef4 gene generating the Arhgef4tm1Taki allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef4 Mutation:  30 strains or lines available
References
Original:  J:159959 Kawasaki Y, et al., The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. J Biol Chem. 2010 Jan 8;285(2):1199-207
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory