About   Help   FAQ
Targeted Allele Detail
Symbol: Arhgef4tm1Taki
Name: Rho guanine nucleotide exchange factor (GEF) 4; targeted mutation 1, Tetsu Akiyama
MGI ID: MGI:4453566
Synonyms: Asef-
Gene: Arhgef4  Location: Chr1:34678188-34813309 bp, + strand  Genetic Position: Chr1, 13.34 cM
Impaired endothelial cell sprouting from Arhgef4tm1Taki/Arhgef4tm1Taki aortas

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:159959
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neo cassette was inserted into exon 2. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:159959)
Targeted disruption of the Arhgef4 gene generating the Arhgef4tm1Taki allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgef4 Mutation:  37 strains or lines available
Original:  J:159959 Kawasaki Y, et al., The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. J Biol Chem. 2010 Jan 8;285(2):1199-207
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory