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| Caption | A, construct containing a portion of the wild-type allele, targeting construct, and recombinant locus generating the Arhgef4tm1Taki allele are shown. Arhgef4 (Asef) was inactivated by the insertion of a neomycin cassette (neo) into codon 73 of Arhgef4. The diphtheria toxin A cassette (DT-A) was placed outside the 3' homologous region for negative selection. The probe P1 used for detection of homologous recombinants is represented by the open bar, and the probe P2 used for detection of a single insertion of the neomycin gene is represented by the filled bar. The primer set used for detection of recombinants is also represented by black arrowheads. ABR, APC-binding region; PH, Pleckstrin homology domain. | ||||
| Copyright | This image is from Kawasaki Y, J Biol Chem 2010 Jan 8;285(2):1199-207 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:159959 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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