Del(7Mrgpra1-Mrgprb4)1And
Targeted Allele Detail

Summary

• Symbol: Del(7Mrgpra1-Mrgprb4)1And
• Name: deletion, Chr 7, David J Anderson 1
• MGI ID: MGI:4436885
• Synonyms: Del1And, Mrgpr-clusterdelta^-
• Gene: Del(7Mrgpra1-Mrgprb4)1And Location: Chr7:46984623-47848926 bp Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157470
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(7Mrgpra1-Mrgprb4)1And involves 30 genes/genome features (Gm22427, Mrgpra1, Gm25326 ...) View all
• Mutation details: The coding exon of MrgprA1 was replaced with a self-excising neo cassette followed by a reverse tetracycline transactivator (rtTA), IRES sequence, and farnesylated EGFP. The coding exon was of MrgprB4 was replaced with a a hygro cassette, loxP site, and human placenta alkaline phosphatase coding sequence. Cre mediated recombination deletes the 845 kb sequence between the two targeted genes, which contains MrgprA10, A2, A14, A3, A12, A16, A19, A4, C11, B5, and 18 other genes. (J:157470)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(7Mrgpra1-Mrgprb4)1And Mutation: 0 strains or lines available

References

• Original: J:157470 Liu Q, et al., Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139(7):1353-65
• All: 13 reference(s)