Del(7Mrgpra1-Mrgprb4)1And Cytogenetic Marker Detail

Summary

• Symbol
  Del(7Mrgpra1-Mrgprb4)1And
• Name
  deletion, Chr 7, David J Anderson 1
• Synonyms
  Mrgpr-cluster delta^-

• Feature Type
  chromosomal deletion
• IDs
  MGI:4436906

Location &
Maps

• Sequence Map
  Chr7:46984623-47848926 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  13 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

The deletion of 845 kb, which removes 12 Mrgprs, results in decreased chloroquine-induced pruritus.

References

• Summaries
  All 13

  Phenotypes 13
• Earliest
  J:157470 Liu Q, et al., Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139(7):1353-65
• Latest
  J:311626 Grundy L, et al., Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension. J Neurosci. 2021 Apr 28;41(17):3900-3916