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Sdhdtm1Jpb
Targeted Allele Detail
Summary
Symbol: Sdhdtm1Jpb
Name: succinate dehydrogenase complex, subunit D, integral membrane protein; targeted mutation 1, Jean-Pierre Bayley
MGI ID: MGI:4418212
Gene: Sdhd  Location: Chr9:50507657-50515112 bp, - strand  Genetic Position: Chr9, 27.75 cM, cytoband B
Alliance: Sdhdtm1Jpb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155380
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-LacZ Neo cassette replaced exon 3 by homologous recombination. Quantitative RT-PCR analysis indicated a 50% reduction in expression in multiple tissues from heterozygous mice. (J:155380)
Generation of Sdhdtm1Jpb allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Sdhdtm1Jpb
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sdhd Mutation:  16 strains or lines available
References
Original:  J:155380 Bayley JP, et al., Sdhd and SDHD/H19 knockout mice do not develop paraganglioma or pheochromocytoma. PLoS One. 2009;4(11):e7987
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory