All Phenotypes Sdhd<tm1Jpb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sdhd^tm1Jpb
targeted mutation 1, Jean-Pierre Bayley
MGI:4418212

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sdhd^tm1Jpb/Sdhd^tm1Jpb	129P2/OlaHsd-Sdhd^tm1Jpb	MGI:4418215
ht2	Sdhd^tm1Jpb/Sdhd⁺	either: 129P2/OlaHsd-Sdhd^tm1Jpb or (involves: 129P2/OlaHsd * C57BL/6J)	MGI:4418214
cx3	H19^tm1Tilg/H19⁺ Sdhd^tm1Jpb/Sdhd⁺	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:4418216

Allelic Composition	Sdhd^tm1Jpb/Sdhd^tm1Jpb
Genetic Background	129P2/OlaHsd-Sdhd^tm1Jpb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhd^tm1Jpb mutation (0 available); any Sdhd mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:155380 )

• die before E10.5

Allelic Composition	Sdhd^tm1Jpb/Sdhd⁺
Genetic Background	either: 129P2/OlaHsd-Sdhd^tm1Jpb or (involves: 129P2/OlaHsd * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhd^tm1Jpb mutation (0 available); any Sdhd mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:155380 )

• viable and fertile with no indications of paraganglioma or pheochromocytoma and no abnormalities detected in the carotid body or adrenal medulla at any age in contrast to expectations from human disease data

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	paraganglioma	DOID:0050773	OMIM:115310 OMIM:168000 OMIM:601650 OMIM:605373 OMIM:614165 OMIM:PS168000	J:155380

Allelic Composition	H19^tm1Tilg/H19⁺ Sdhd^tm1Jpb/Sdhd⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19^tm1Tilg mutation (1 available); any H19 mutation (12 available)
Sdhd^tm1Jpb mutation (0 available); any Sdhd mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:155380 )

N	• no paragangliomas nor pheochromocytomas are detected in mice at up to 29 months of age in contrast to expectations from human disease data

nervous system

nervous system phenotype ( J:155380 )

N	• no significant changes in carotid body or the adrenal medulla are seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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