Macrod2^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Macrod2^{tm1(KOMP)Vlcg}
• Name: mono-ADP ribosylhydrolase 2; targeted mutation 1, Velocigene
• MGI ID: MGI:4415493
• Gene: Macrod2 Location: Chr2:140237229-142234886 bp, + strand Genetic Position: Chr2, 69.2 cM, cytoband G3
• Alliance: Macrod2^{tm1(KOMP)Vlcg} page
• IMPC: Macrod2 gene page

Mutation origin

• Mutant Cell Lines: 12650A-B1, 12650A-B5, 12650A-C6, 12650A-D6, 12650A-G2
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 19224bp between positions 140242896-140262119 of Chromosome 2 (Build GRCm39). Immunoblot analysis confirmed the absence of protein expression in testis and liver extracts from homozygous mutant mice. (J:136110, J:271238)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Macrod2 Mutation: 38 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 3 reference(s)