normal phenotype
• homozygotes are viable, healthy and overtly normal and show no significant changes in gamma-irradiation induced lethality, high fat diet-induced obesity, or response to glucose or insulin challenge relative to wild-type controls
• in response to gamma-irradiation, mouse embryonic fibroblasts (MEFs) isolated from E10.5 embryos exhibit DNA damage levels comparable to those observed in wild-type MEFs
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