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Atf4tm1Kry
Targeted Allele Detail
Nomenclature
Symbol: Atf4tm1Kry
Name: activating transcription factor 4; targeted mutation 1, Gerard Karsenty
MGI ID: MGI:4360484
Synonyms: Atf4fl
Gene: Atf4  Location: Chr15:80255184-80257541 bp, + strand  Genetic Position: Chr15, 37.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:152695
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3. However, further sequencing analysis revealed that the insertion of the loxp cassette disrupted the first splice site and resulted in an allele that, in contrast to the wildtype allele, did not result in expression of encoded protein. (J:152695, J:253375)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atf4 Mutation:  17 strains or lines available
References
Original:  J:152695 Yoshizawa T, et al., The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest. 2009 Sep;119(9):2807-17
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory