Phenotypes associated with this allele

• Allele Symbol: Atf4^tm1Kry
• Allele Name: targeted mutation 1, Gerard Karsenty
• Allele ID: MGI:4360484
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atf4^tm1Kry/Atf4^tm1Kry Creb1^tm3Gsc/Creb1^tm3Gsc Tg(Col1a1-cre)1Kry/0	involves: 129P2/OlaHsd * C57BL/6J * FVB	MGI:4360509
cn2	Atf4^tm1Kry/Atf4^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: C57BL/6J * FVB	MGI:4360510

Genotype
MGI:4360509

cn1

• Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry; Creb1^tm3Gsc/Creb1^tm3Gsc; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:152695 )

N • mice exhibit normal glucose and insulin homeostasis

Genotype
MGI:4360510

cn2

• Allelic Composition: Atf4^tm1Kry/Atf4^tm1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: C57BL/6J * FVB

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:152695 )

N • serum leptin, resistin, and adiponectin levels are normal

abnormal glucose homeostasis ( J:152695 )

• insulin-stimulated whole-body glucose turnover is increased 40% compared to in similarly treated wild-type mice

increased insulin secretion ( J:152695 )

• following glucose challenge

decreased circulating glucose level ( J:152695 )

• at 2 weeks and 1 month

impaired gluconeogenesis ( J:152695 )

• reduced after pyruvate challenge

improved glucose tolerance ( J:152695 )

abnormal glycogen homeostasis ( J:152695 )

• insulin-stimulated whole-body glycogen synthesis is increased compared to in similarly treated wild-type mice

increased insulin sensitivity ( J:152695 )

endocrine/exocrine glands

increased insulin secretion ( J:152695 )

• following glucose challenge

growth/size/body

decreased body weight ( J:152695 )