Lck^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Lck^tm1Litt
• Name: lymphocyte protein tyrosine kinase; targeted mutation 1, Dan R Littman
• MGI ID: MGI:4358983
• Gene: Lck Location: Chr4:129442142-129467415 bp, - strand Genetic Position: Chr4, 63.26 cM, cytoband distal
• Alliance: Lck^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152472
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream of the translation initiation codon in exon 1 and downstream of exon 3. (J:152472)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lck Mutation: 93 strains or lines available

References

• Original: J:152472 Kim JK, et al., Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One. 2009;4(8):e6580
• All: 1 reference(s)