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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lcktm1Litt
targeted mutation 1, Dan R Littman
MGI:4358983
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fyntm1Sor/Fyntm1Sor
Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+ 		involves: 129S7/SvEvBrd * 129X1/SvJ MGI:4359000
cn2
 		Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+ 		involves: 129X1/SvJ MGI:4358999


Genotype
MGI:4359000
cn1
Allelic
Composition		 Fyntm1Sor/Fyntm1Sor
Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyntm1Sor mutation (3 available); any Fyn mutation (37 available)
Lcktm1.1Litt mutation (0 available); any Lck mutation (93 available)
Lcktm1Litt mutation (0 available); any Lck mutation (93 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:152472 )
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
decreased regulatory T cell number ( J:152472 )
• in the thymus and spleen
abnormal regulatory T cell physiology ( J:152472 )
• regulatory T cell turnover is impaired and suppressive function is lost

hematopoietic system
decreased T cell proliferation ( J:152472 )
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
decreased regulatory T cell number ( J:152472 )
• in the thymus and spleen
abnormal regulatory T cell physiology ( J:152472 )
• regulatory T cell turnover is impaired and suppressive function is lost

cellular
decreased T cell proliferation ( J:152472 )
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells




Genotype
MGI:4358999
cn2
Allelic
Composition		 Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcktm1.1Litt mutation (0 available); any Lck mutation (93 available)
Lcktm1Litt mutation (0 available); any Lck mutation (93 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:152472 )
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
decreased regulatory T cell number ( J:152472 )
• in the thymus and spleen
abnormal regulatory T cell physiology ( J:152472 )
• regulatory T cell turnover is impaired and suppressive function is lost

hematopoietic system
decreased T cell proliferation ( J:152472 )
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells
decreased regulatory T cell number ( J:152472 )
• in the thymus and spleen
abnormal regulatory T cell physiology ( J:152472 )
• regulatory T cell turnover is impaired and suppressive function is lost

cellular
decreased T cell proliferation ( J:152472 )
• CD25+ T cells fail to proliferate when transferred into T cell-deficient recipients unlike similarly treated wild-type cells
• CD25- T cells exhibit reduced proliferation when transferred into T cell deficient recipients compared with similarly treated wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory