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AmfrGt(IST12797A11)Tigm
Gene trapped Allele Detail
Nomenclature
Symbol: AmfrGt(IST12797A11)Tigm
Name: autocrine motility factor receptor; gene trap IST12797A11, Texas A&M Institute for Genomic Medicine
MGI ID: MGI:4093875
Synonyms: gp78-KO
Gene: Amfr  Location: Chr8:93971588-94012640 bp, - strand  Genetic Position: Chr8, 45.96 cM
Mutation
origin
Mutant Cell Line:  IST12797A11
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  Lex3.13 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Gene trapped (Null/knockout)
Mutation:    Insertion of gene trap vector     Vector: VICTR76     Vector Type: gene trap
 
Mutation detailsSequence tags for this gene trap insertion do not overlap a single known gene in the trapped gene orientation. It is possible that sequence tags for this gene trap overlap multiple genes in the trapped gene orientation, one or more genes in reverse orientation (not disrupted by the gene trap mechanism), or no known genes (using current gene model coordinates). J:221247 reports that the gene-trapping vector was inserted in the first intron downstream of the ATG codon between the first and second exons, which block production of endogenous transcription. RT-PCR and Western blot analysis confirmed absence of mRNA or protein in homozygous embryonic lysate or liver tissue. (J:221247)
Sequence Tags: 
Sequence tag details (2 tags)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Amfr Mutation:  29 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Nonalcoholic Steatohepatitis (NASH) J:221247.
References
Original:  J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory