Phenotypes associated with this allele

• Allele Symbol: Amfr^{Gt(IST12797A11)Tigm}
• Allele Name: gene trap IST12797A11, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4093875
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amfr^Gt(IST12797A11)Tigm/Amfr^Gt(IST12797A11)Tigm	C57BL/6-Amfr^Gt(IST12797A11)Tigm	MGI:5699972

Genotype
MGI:5699972

hm1

• Allelic Composition: Amfr^{Gt(IST12797A11)Tigm}/Amfr^{Gt(IST12797A11)Tigm}
• Genetic Background: C57BL/6-Amfr^{Gt(IST12797A11)Tigm}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:221247 )

• more than 70% of mice grow fat with abdominal obesity at around 1 year of age

immune system

liver inflammation ( J:221247 )

• hepatic inflammation, characterized by the infiltration of inflammatory cells in which lymphocytes infiltrate, gather, and interface among liver lobules regardless of fat accumulation

• hepatitis is likely to be independent of steatohepatitis progression

liver/biliary system

liver inflammation ( J:221247 )

• hepatic inflammation, characterized by the infiltration of inflammatory cells in which lymphocytes infiltrate, gather, and interface among liver lobules regardless of fat accumulation

• hepatitis is likely to be independent of steatohepatitis progression

abnormal liver morphology ( J:221247 )

• liver of obese aged mice develops simple steatosis and/or hepatic inflammation to varying degrees indicating the development of nonalcoholic steatohepatitis

abnormal hepatocyte morphology ( J:221247 )

• hepatocytes are enlarged and distended by large single or multiple well-defined droplets of fat

hepatic steatosis ( J:221247 )

• accumulation of lipids in the liver

• mice injected with tunicamycin in the liver at 6 months of age to induce acute ER stress show greater steatosis in the entire liver compared to local and partial areas of steatosis in wild-type mice

• mice injected with tunicamycin in the liver at 11 days of age exhibit persistent steatosis and progression of fibrosis while wild-type mice recover fully

liver cirrhosis ( J:221247 )

liver fibrosis ( J:221247 )

• irregular distribution of collagen fibers in the liver, indicative of liver injury and fibrosis

• 2 of 6 mice with liver tumors have severe fibrosis in another liver lobe distant from the tumor region

increased liver tumor incidence ( J:221247 )

• 6 of 25 mice develop liver tumors; aged mice have dysplastic foci but no tumors in other organs

neoplasm

increased liver tumor incidence ( J:221247 )

• 6 of 25 mice develop liver tumors; aged mice have dysplastic foci but no tumors in other organs

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:221247 )

• MEFs are more sensitive to tunicamycin treatment, showing reduced survival rate compared to wild-type MEFs

• mice injected with tunicamycin in the liver at 6 months of age to induce acute ER stress show greater steatosis in the entire liver compared to local and partial areas of steatosis in wild-type mice

• mice injected with tunicamycin in the liver at 11 days of age exhibit persistent steatosis and progression of fibrosis while wild-type mice recover fully