Gucy2g^tm1Rbya
Targeted Allele Detail

Summary

• Symbol: Gucy2g^tm1Rbya
• Name: guanylate cyclase 2g; targeted mutation 1, Ruey-Bing Yang
• MGI ID: MGI:3850214
• Synonyms: GC-G^-
• Gene: Gucy2g Location: Chr19:55186531-55229668 bp, - strand Genetic Position: Chr19, 51.18 cM, cytoband D2
• Alliance: Gucy2g^tm1Rbya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150175
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was replaced with a neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of expression in the kidney and kidney and sperm, respectively, from homozygous mice. (J:150175)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gucy2g Mutation: 60 strains or lines available

References

• Original: J:150175 Lin H, et al., Disruption of guanylyl cyclase-G protects against acute renal injury. J Am Soc Nephrol. 2008 Feb;19(2):339-48
• All: 6 reference(s)