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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gucy2gtm1Rbya
targeted mutation 1, Ruey-Bing Yang
MGI:3850214
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gucy2gtm1Rbya/Gucy2gtm1Rbya B6.Cg-Gucy2gtm1Rbya MGI:3850215


Genotype
MGI:3850215
hm1
Allelic
Composition		 Gucy2gtm1Rbya/Gucy2gtm1Rbya
Genetic
Background		 B6.Cg-Gucy2gtm1Rbya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gucy2gtm1Rbya mutation (0 available); any Gucy2g mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:150175 )
N
• in the absence of ischemia injury, no abnormalities are seen in kidney histology or function
decreased susceptibility to kidney reperfusion injury ( J:150175 )
• decrease in the severity of renal dysfunction and tubular necrosis following ischemia/reperfusion injury of the kidney
• following ischemia/reperfusion injury of the kidney fewer polymorphonuclear cells and fewer apoptotic epithelial cells are found in the kidneys

homeostasis/metabolism
decreased susceptibility to kidney reperfusion injury ( J:150175 )
• decrease in the severity of renal dysfunction and tubular necrosis following ischemia/reperfusion injury of the kidney
• following ischemia/reperfusion injury of the kidney fewer polymorphonuclear cells and fewer apoptotic epithelial cells are found in the kidneys




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory