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Targeted Allele Detail
Symbol: Cavin3tm1(KOMP)Vlcg
Name: caveolae associated 3; targeted mutation 1, Velocigene
MGI ID: MGI:3847505
Gene: Cavin3  Location: Chr7:105480616-105482197 bp, - strand  Genetic Position: Chr7, 55.87 cM, cytoband F1
Mutant Cell Lines:  11448A-A5, 11448A-A12, 11448A-C3, 11448A-C6, 11448A-D8
Germline Transmission:  Earliest citation of germline transmission: J:205741
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 1369bp between positions 112629302-112630670 of Chromosome 7 (Genome Build37). The cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in the lung, heart, fat, skeletal muscle, brain and liver. (J:136110, J:205741)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 2 lines available
Carrying any Cavin3 Mutation:  8 strains or lines available
Cell line 11448A-D8 was successfully used to make chimeric mice. Germline transmission was accomplished. J:205741
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory