About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cavin3tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:3847505
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg involves: C57BL/6 * C57BL/6NTac MGI:5549945
cx2
 		Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg
Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg 		involves: C57BL/6 * C57BL/6NTac MGI:5549946


Genotype
MGI:5549945
hm1
Allelic
Composition		 Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Cell Lines 11448A-D8
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cavin3tm1(KOMP)Vlcg mutation (1 available); any Cavin3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:205741 )
N
• lung vascular endothelial is normal

cellular
cellular phenotype ( J:205741 )
N
• endothelial caveolae formation is normal




Genotype
MGI:5549946
cx2
Allelic
Composition		 Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg
Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Cell Lines 11448A-D8, 11065A-H7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cavin2tm1(KOMP)Vlcg mutation (0 available); any Cavin2 mutation (23 available)
Cavin3tm1(KOMP)Vlcg mutation (1 available); any Cavin3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular endothelial cell morphology ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination
• however, calveolae in the heart is normal
abnormal pulmonary endothelial cell surface ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination

cellular
abnormal plasma membrane morphology ( J:205741 )
• lung endothelia contain very few caveolae
• however, calveolae in the heart is normal

respiratory system
abnormal pulmonary endothelial cell surface ( J:205741 )
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory