Camk2dtm1.2Eno
Targeted Allele Detail
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Symbol: |
Camk2dtm1.2Eno |
Name: |
calcium/calmodulin-dependent protein kinase II, delta; targeted mutation 1.2, Eric N Olson |
MGI ID: |
MGI:3837728 |
Synonyms: |
CaMKIIdelta- |
Gene: |
Camk2d Location: Chr3:126389951-126639975 bp, + strand Genetic Position: Chr3, 55.97 cM
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Alliance: |
Camk2dtm1.2Eno page
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Diminished cardiac hypertrophy of Camk2dtm1.2Eno/Camk2dtm1.2Eno mice after thoracic aortic constriction
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:146285
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEvBrd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Germ line, cre mediated recombination was used to remove exons 1 and 2. The absence of protein expression was confirmed by western blot analysis on cardiac extracts.
(J:146285)
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Generation of the Camk2dtm1.1Eno and Camk2dtm1.2Eno alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Camk2d Mutation: |
43 strains or lines available
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Original: |
J:146285 Backs J, et al., The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7 |
All: |
11 reference(s) |
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