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| Caption | Generation of the Camk2dtm1.1Eno and Camk2dtm1.2Eno alleles. Camk2d protein structure, intron-exon structure of the gene, and gene targeting strategy. LoxP sites were inserted in the introns flanking exons 1 and 2. Exon 2 encodes the ATP-binding motif required for kinase function. The neomycin resistance cassette (neo) was removed in the mouse germ line by breeding heterozygous mice to hACTB::FLPe transgenic mice generating the Camk2dtm1.1Eno allele, and deletion of exons 1 and 2 was achieved by breeding to CAG-Cre transgenic mice, generating the Camk2dtm1.2Eno allele. | ||||||
| Copyright | This image is from Backs J, Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2342-7. Copyright 2009 National Academy of Sciences, U.S.A. J:146285 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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