Camk2d^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Camk2d^tm1.1Eno
• Name: calcium/calmodulin-dependent protein kinase II, delta; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:3837727
• Gene: Camk2d Location: Chr3:126389951-126639975 bp, + strand Genetic Position: Chr3, 55.97 cM
• Alliance: Camk2d^tm1.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146285
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1, and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 1 and 2 floxed. (J:146285)

Generation of the Camk2d^tm1.1Eno and Camk2d^tm1.2Eno alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2d Mutation: 44 strains or lines available

References

• Original: J:146285 Backs J, et al., The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2342-7
• All: 11 reference(s)