Htr2b^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Htr2b^tm1Kry
• Name: 5-hydroxytryptamine (serotonin) receptor 2B; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:3837400
• Gene: Htr2b Location: Chr1:86026748-86039692 bp, - strand Genetic Position: Chr1, 43.94 cM
• Alliance: Htr2b^tm1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146078
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted before exon 2 and a floxed neo cassette in inverse orientation was inserted after exon 2 via homologous recombination. The neo cassette was later removed leaving exon 2 floxed. (J:146078)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr2b Mutation: 27 strains or lines available

References

• Original: J:146078 Yadav VK, et al., Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell. 2008 Nov 28;135(5):825-37
• All: 7 reference(s)