Phenotypes associated with this allele

• Allele Symbol: Htr2b^tm1Kry
• Allele Name: targeted mutation 1, Gerard Karsenty
• Allele ID: MGI:3837400
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Htr2b^tm1Kry/Htr2b^tm1Kry Tg(Ins2-cre)23Herr/0	involves: C57BL/6J * CBA/J	MGI:6400802
cn2	Htr2b^tm1Kry/Htr2b^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: FVB	MGI:3837410

Genotype
MGI:6400802

cn1

• Allelic Composition: Htr2b^tm1Kry/Htr2b^tm1Kry; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:284574 )

• at P0 without an increase in apoptosis

• however, adult beta cell proliferation is normal

decreased pancreatic beta cell mass ( J:284574 )

• at P0 and in adults without a change in pancreas weight

homeostasis/metabolism

decreased circulating insulin level ( J:284574 )

• in fasting mice and after glucose stimulation

cellular

decreased pancreatic beta cell proliferation ( J:284574 )

• at P0 without an increase in apoptosis

• however, adult beta cell proliferation is normal

Genotype
MGI:3837410

cn2

• Allelic Composition: Htr2b^tm1Kry/Htr2b^tm1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: FVB

skeleton

skeleton phenotype ( J:146078 )

N • despite loss of expression in osteoblasts, no skeletal abnormalities are detected at 1 or 3 months of age