Tnfrsf9^tm1Lpc
Targeted Allele Detail

Summary

• Symbol: Tnfrsf9^tm1Lpc
• Name: tumor necrosis factor receptor superfamily, member 9; targeted mutation 1, Lieping Chen
• MGI ID: MGI:3834749
• Synonyms: CD137^-
• Gene: Tnfrsf9 Location: Chr4:151004612-151030561 bp, + strand Genetic Position: Chr4, 81.52 cM
• Alliance: Tnfrsf9^tm1Lpc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145439
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The signal peptide with the ATG translation initiation codon and the first 6 exons encoding the extracellular and transmembrane regions were replaced with a neo cassette. The absence of protein expression was confirmed by analysis of Con A-activated spleen cells. (J:145439)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf9 Mutation: 46 strains or lines available

References

• Original: J:145439 Zhu Y, et al., CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood. 2007 Jun 1;109(11):4882-9
• All: 5 reference(s)