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Targeted Allele Detail
Symbol: Tnfrsf9tm1Lpc
Name: tumor necrosis factor receptor superfamily, member 9; targeted mutation 1, Lieping Chen
MGI ID: MGI:3834749
Synonyms: CD137-
Gene: Tnfrsf9  Location: Chr4:150914562-150946102 bp, + strand  Genetic Position: Chr4, 81.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:145439
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe signal peptide with the ATG translation initiation codon and the first 6 exons encoding the extracellular and transmembrane regions were replaced with a neo cassette. The absence of protein expression was confirmed by analysis of Con A-activated spleen cells. (J:145439)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf9 Mutation:  20 strains or lines available
Original:  J:145439 Zhu Y, et al., CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood. 2007 Jun 1;109(11):4882-9
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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