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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf9tm1Lpc
targeted mutation 1, Lieping Chen
MGI:3834749
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf9tm1Lpc/Tnfrsf9tm1Lpc B6.129-Tnfrsf9tm1Lpc MGI:3834762


Genotype
MGI:3834762
hm1
Allelic
Composition		 Tnfrsf9tm1Lpc/Tnfrsf9tm1Lpc
Genetic
Background		 B6.129-Tnfrsf9tm1Lpc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf9tm1Lpc mutation (0 available); any Tnfrsf9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:145439 )
N
• mice exhibit normal T cell development and polyclonal activation
abnormal memory T cell physiology ( J:145439 )
• when cells are transplanted into congenic Thy1.1 C57BL/6 mice and stimulated with Tnfsf9 antibody, memory T cells fail to expand unlike when wild-type cells are used in the transplant assay
• however, memory T cells response normally to polyI:C and wild-type cells transplanted into mice respond normally toTnfsf9 antibodies

hematopoietic system
abnormal memory T cell physiology ( J:145439 )
• when cells are transplanted into congenic Thy1.1 C57BL/6 mice and stimulated with Tnfsf9 antibody, memory T cells fail to expand unlike when wild-type cells are used in the transplant assay
• however, memory T cells response normally to polyI:C and wild-type cells transplanted into mice respond normally toTnfsf9 antibodies




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory