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Tc(HSA21)1TybEmcf
Allele Detail
Nomenclature
Symbol: Tc(HSA21)1TybEmcf
Name: transchromosomal, human 21, line 1, Victor Tybulewicz and Elizabeth M C Fisher
MGI ID: MGI:3814712
Synonyms: Tc1, Tc(HSA21)91-1Emcf
Gene: Tc(HSA21)1TybEmcf  Location: unknown  
Mutation
origin
Mutant Cell Line:  91-1
Germline Transmission:  Earliest citation of germline transmission: J:101383
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Not Applicable (Humanized sequence, Inserted expressed sequence)
Mutation:    Other
 
Mutation detailsA freely segregating chromosome composed of 42 Mb, or 90%, of human chromosome 21 (spanning D21S5-CXADR, D21S1922-IFNAR1 and RUNX1-COL6A1) was created in MPI-VI (129S2/SvPas) ES cells using irradiated microcell-mediated chromosome transfer. (J:101383)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Tc(HSA21)1TybEmcf Mutation:  3 strains or lines available
Notes
ES cell line = MPI-VI.
References
Original:  J:101383 O'Doherty A, et al., An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science. 2005 Sep 23;309(5743):2033-7
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory