Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(10Prmt2-Cstb)4Yah mutation
(1 available);
any
Del(10Prmt2-Cstb)4Yah mutation
(1 available)
Tc(HSA21)1TybEmcf mutation
(3 available);
any
Tc(HSA21)1TybEmcf mutation
(4 available)
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behavior/neurological
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• slower to learn task in a Morris Maze test
• travelled further to find the hidden platform
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• little retention of learning seen during probe trials in a Morris Maze test
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• less time spent in the periphery of an open field test
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• perform poorly on a rotarod
• fall of a rotarod more rapidly and at slower speeds
• rotarod performance does not improve with practice
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• 25% more errors than controls on a notched bar test of hindlimb performance
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• investigation of a newly introduced mouse is normal
• no distinction made between mice after the later introduction of a second new mouse
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Allelic Composition |
Tc(HSA21)1TybEmcf/0
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Genetic Background |
involves: 129P2/OlaHsd * BALB/c * C3H/HeH * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tc(HSA21)1TybEmcf mutation
(3 available);
any
Tc(HSA21)1TybEmcf mutation
(4 available)
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behavior/neurological
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• slower to learn task in a Morris Maze test
• travelled further to find the hidden platform
|
|
• little retention of learning seen during probe trials in a Morris Maze test
|
|
• less time spent in the periphery of an open field test
|
|
• perform poorly on a rotarod
• fall of a rotarod more rapidly and at slower speeds
• rotarod performance does not improve with practice
|
|
• 25% more errors than controls on a notched bar test of hindlimb performance
|
|
• no distinction made between mice after the later introduction of a second new mouse
• investigation of a newly introduced mouse is normal
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Allelic Composition |
Tc(HSA21)1TybEmcf/0
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Genetic Background |
involves: 129S2/SvPas * 129S8/SvEv * C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tc(HSA21)1TybEmcf mutation
(3 available);
any
Tc(HSA21)1TybEmcf mutation
(4 available)
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cardiovascular system
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• seen in mice with a full atrioventricular canal defect
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• in one mouse that also displayed a ventricular septum defect
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• some mice exhibit hearts that are tilted onto their right unlike in wild-type mice
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• one mouse exhibited an atrioventricular septal defect associated with unfused atrioventricular cushions
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• 7 of 11 mice exhibit a perimembranous ventral septal defect such that the ventricular septum fails to fuse to the proximal outflow cushion tracts
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nervous system
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• mice exhibit a reduction in the number of granule neurons in the cerebellum compared to wild-type mice
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behavior/neurological
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• mice spend less time exploring a novel object than wild-type mice
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craniofacial
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• mutant mice exhibit a mandible that is smaller between the coronoid process and the mandibular angle and between the coronoid process and the most superior point of the incisor alveolar rim
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skeleton
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• mutant mice exhibit a mandible that is smaller between the coronoid process and the mandibular angle and between the coronoid process and the most superior point of the incisor alveolar rim
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