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Targeted Allele Detail
Symbol: Alox12btm1.1Krie
Name: arachidonate 12-lipoxygenase, 12R type; targeted mutation 1.1, Peter Krieg
MGI ID: MGI:3795936
Gene: Alox12b  Location: Chr11:69157072-69169791 bp, + strand  Genetic Position: Chr11, 42.38 cM
Impaired epidermal barrier in Alox12btm1.1Krie/Alox12btm1.1Krie mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:134709
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsHeterozygous Alox12btm1Krie mice was crossed with deleter mice expressing Cre recombinase resulting in excision of the tk/neo selection cassette and exon 8. The mutated RNA expression was confirmed by RT-PCR, however, no protein product was detected by Western blot. (J:134709)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alox12b Mutation:  23 strains or lines available
Original:  J:134709 Epp N, et al., 12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol. 2007 Apr 9;177(1):173-82
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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