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Leprtm2(cre)Rck
Targeted Allele Detail
Nomenclature
Symbol: Leprtm2(cre)Rck
Name: leptin receptor; targeted mutation 2, Jeffrey M Friedman
MGI ID: MGI:3776158
Synonyms: LepRbCre, LepRb-IRES-Cre, Leprcre, ObRb-Cre, Obrb-IRES-Cre
Gene: Lepr  Location: Chr4:101717404-101815352 bp, + strand  Genetic Position: Chr4, 46.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68414
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cre recombinase expression cassette containing an IRES domain and a FRT-flanked neomcyin cassette was placed immediately downstream of the stop codon for the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre expression in the hypothalamus was confirmed by use of a virus containing a cre-dependent reporter gene. (J:68414)
Recombinase
activity
Activity:
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Driver: Lepr     Summary of all recombinase alleles driven by Lepr. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  84 strains or lines available
References
Original:  J:68414 DeFalco J, et al., Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science. 2001 Mar 30;291(5513):2608-13
All:  57 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory