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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Leprtm2(cre)Rck
targeted mutation 2, Jeffrey M Friedman
MGI:3776158
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Tg(Tek-cre)12Flv/0 		involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL MGI:5306357
cn2
 		Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+ 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL MGI:5306356
cn3
 		Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Leprtm2(cre)Rck/Lepr+ 		involves: C57BL/6 MGI:5488610


Genotype
MGI:5306357
cn1
Allelic
Composition		 Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (123 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system

growth/size/body
spleen hyperplasia ( J:180431 )




Genotype
MGI:5306356
cn2
Allelic
Composition		 Kitltm1.1Sjm/Kitltm2.1Sjm
Leprtm2(cre)Rck/Lepr+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased hematopoietic cell number ( J:180431 )
• in the bone marrow and the spleen
• depletion in the bone marrow increases over time

immune system

growth/size/body
enlarged spleen ( J:180431 )
spleen hyperplasia ( J:180431 )




Genotype
MGI:5488610
cn3
Allelic
Composition		 Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Leprtm2(cre)Rck/Lepr+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (24 available)
Leprtm2(cre)Rck mutation (1 available); any Lepr mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic system morphology/development ( J:194748 )
• increased hematopoietic cells and colony forming cells in the blood and spleen




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory