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Tg(Ins2-H2-Ead,Ins2-H2-Eb1b)187-7Bri
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-H2-Ead,Ins2-H2-Eb1b)187-7Bri
Name: transgene insertion 187-7, Ralph L Brinster
MGI ID: MGI:3766019
Synonyms: I-E, Ins-IE, Insl-E
Transgene: Tg(Ins2-H2-Ead,Ins2-H2-Eb1b)187-7Bri  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details2 independent constructs consisting of a 600 bp fragment of the 5' sequences driving the H2-Ead and a 600 bp fragment of 5' sequence driving the H2-Eb1b gene were coinjected into fertilized pronuclei. Four founders with germline transmission were identified and 3 (187-1, 187-7, and 190-5) were further studied. 187-7 (male) was chosen as representative, since it apparently characterized most thoroughly. (J:127706)
Phenotypes
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:127706 Lo D, et al., Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell. 1988 Apr 8;53(1):159-68
All:  3 reference(s)

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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory