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Cacnb2tm1.1Mfre
Targeted Allele Detail
Nomenclature
Symbol: Cacnb2tm1.1Mfre
Name: calcium channel, voltage-dependent, beta 2 subunit; targeted mutation 1.1, Marc Freichel
MGI ID: MGI:3762348
Synonyms: Cavbeta2-
Gene: Cacnb2  Location: Chr2:14603088-14987908 bp, + strand  Genetic Position: Chr2, 10.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126506
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 16 was removed by cre-mediated recombination. This exon encodes part of the SH3 domain and the guanylate kinase domain. The absence of protein expression was confirmed by western blot analysis on E10.5 hearts. (J:126506)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacnb2 Mutation:  25 strains or lines available
References
Original:  J:126506 Weissgerber P, et al., Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29;99(7):749-57
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory