Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1.1Mfre mutation
(0 available);
any
Cacnb2 mutation
(50 available)
Cacnb2tm1Mfre mutation
(0 available);
any
Cacnb2 mutation
(50 available)
Myl2tm1(cre)Krc mutation
(2 available);
any
Myl2 mutation
(22 available)
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mortality/aging
cardiovascular system
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• the beating frequency of E13.5 heart explants is reduced compared to for wild-type hearts
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• calcium channel current density is reduced compared to in wild-type mice (-12.3+/-0.6 mV compared to -16.9+/-07 mV in wild-type mice)
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embryo
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• between E11.5 and E12.5, vascular remodeling of the primary capillary plexus fails to occur and a honeycomb-like network of tubules with enlarged and uniform diameters forms in the extra- and intraembryonic vasculature
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1.1Mfre mutation
(0 available);
any
Cacnb2 mutation
(50 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
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mortality/aging
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• mice die following E10.5 and are completely absorbed by E11.5
• however, treatment with a calcium channel agonist, 1 umol/L (-)-BayK 8644, partially rescues embryonic lethality with mice surviving until the end of E11.5
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cardiovascular system
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• at E10.5, a stenosis is frequently observed between the emerging right ventricle and the outflow tract
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• at E10.5, mice display abnormal heart looping
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• at E10.5, mice display abnormal heart looping with amorphous heart tubes lying distorted within the pericardial cavity, and a stenosis is frequently observed between the emerging right ventricle and the outflow tract
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• at E10.5, pericardial effusion is associated with hemorrhages
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• at E10.5, hearts only exhibit barely noticeable tremors without any noticeable ejection volume
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• at E10.5, pericardial effusion is associated with hemorrhages
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• 63+/-2.88 beats per minute compared to 120+/-3.15 beats per minute in wild-type mice
• however, no difference in heart rate is observed at E9.5
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• at E10.5, L-type calcium channel activity and calcium-induced calcium release is impaired resulting in diminished heart pumping
• calcium channel current density is reduced compared to in wild-type mice
• unlike wild-type cardiomyocytes, E9.5 cardiomyocytes fail to respond to catecholamine treatment
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embryo
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• unlike in wild-type mice, embryos size does not double between E9.5 and E10.5
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• at E9.5, vascular remodeling of the primary capillary plexus fails to occur and a honeycomb-like network of tubules with enlarged and uniform diameters forms in the extra- and intraembryonic vasculature
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nervous system
growth/size/body
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• between E9.5 and E10.5, mice exhibit poor growth of facial primordial tissue
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• unlike in wild-type mice, embryos size does not double between E9.5 and E10.5
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craniofacial
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• between E9.5 and E10.5, mice exhibit poor growth of facial primordial tissue
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homeostasis/metabolism
hematopoietic system
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• very few hemangioblasts are found in the blood vessels of the yolk sac
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muscle
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