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Targeted Allele Detail
Symbol: Hace1tm1Pngr
Name: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; targeted mutation 1, Josef M Penninger
MGI ID: MGI:3759063
Synonyms: Hace1-
Gene: Hace1  Location: Chr10:45577829-45712345 bp, + strand  Genetic Position: Chr10, 23.65 cM
Germline Transmission:  Earliest citation of germline transmission: J:125183
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 and 4, which encode the first two ankyrin repeats, were replaced with a neo cassette. The absence of transcript was confirmed by RT-PCR and northern blot analysis on kidney and embryonic fibroblasts. The absence of protein product was confirmed by western blot analysis on kidney tissue. (J:125183)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hace1 Mutation:  19 strains or lines available
Original:  J:125183 Zhang L, et al., The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 2007 Oct;13(9):1060-1069
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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