Analysis Tools
neoplasm
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• starting at week 20, mice develop spontaneous tumors as they age including melanomas, hepatocellular carcinomas, spontaneous lung adenocarcinomas, angiosarcomas, mammary carcinomas, lymphomas, sarcomas, and lung and soft tissue tumors
• by 2 years of age, the incidence of spontaneous tumor reaches about 12% compared to 1 to 2% in wild-type and heterozygous mice
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• mice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotypemice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotype
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• mice exhibit multifocal, large and rapidly growing lung tumors in response to urethane unlike similarly treated wild-type mice that do not develop lung tumors
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respiratory system
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• mice exhibit multifocal, large and rapidly growing lung tumors in response to urethane unlike similarly treated wild-type mice that do not develop lung tumors
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endocrine/exocrine glands
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• mice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotypemice treated with a dose of gamma radiation that induces a very low incidence of thymic lymphomas exhibit a 30% incidence with a CD4-CD8-TCRalphabetalow phenotype
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