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Artm1Fcl
Targeted Allele Detail
Nomenclature
Symbol: Artm1Fcl
Name: androgen receptor; targeted mutation 1, Frank Claessens
MGI ID: MGI:3706240
Synonyms: SPARKI
Gene: Ar  Location: ChrX:98149721-98323215 bp, + strand  Genetic Position: ChrX, 42.82 cM
Histochemical analysis of wild type and Artm1Fcl/Y testes

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120102
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe second zinc-finger of the locus, encoded by exon 3, was replaced by exon 4 of the nuclear receptor subfamily 3, group C, member 1, resulting in a chimeric protein. A floxed neo was included in the vector downstream of the exon substitution and was subsequently removed via cre mediated recombination. (J:120102)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ar Mutation:  13 strains or lines available
References
Original:  J:120102 Schauwaers K, et al., Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4961-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory