Mogtm1(cre)Gkl
Targeted Allele Detail
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Symbol: |
Mogtm1(cre)Gkl |
Name: |
myelin oligodendrocyte glycoprotein; targeted mutation 1, George Kollias |
MGI ID: |
MGI:3689957 |
Synonyms: |
MOGi-cre |
Gene: |
Mog Location: Chr17:37321635-37334290 bp, - strand Genetic Position: Chr17, 19.16 cM, cytoband C
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Alliance: |
Mogtm1(cre)Gkl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:114741
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Mogtm1(cre)Gkl expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Mog (MGI:97435) |
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Mutation details: The open reading frame of the Cre recombinase gene, followed by the human growth hormone polyadenylation signal and the neomycin resistance gene, has replaced all except the 5'-most segment of the first exon, the first intron and all but the 3'-most part of the second exon of the myelin oligodendrocyte glycoprotein gene, thus targeting Cre expression to oligodendrocytes (ODCs). Western blot analysis demonstrated that wild-type MOG protein is present in heterozygous and wild-type brains at comparable levels, but is not detectable in homozygous mutant brain.
(J:114741)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Mog
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:114741 Hovelmeyer N, et al., Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 1;175(9):5875-84 |
All: |
20 reference(s) |
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