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Targeted Allele Detail
Symbol: Cd79atm1(cre)Reth
Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1, Michael Reth
MGI ID: MGI:3687451
Synonyms: Cd79a-Cre, mb1-cre, mb.1-Cre, mb1Cre, Mb-1Cre
Gene: Cd79a  Location: Chr7:24897381-24902197 bp, + strand  Genetic Position: Chr7, 13.49 cM
Small spleen size in Atmintm1.2Jhh/Atmintm1.2Jhh/ Cd79atm1(cre)Reth/Cd79a+ mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:113645
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Mutation detailsExons 2 and 3 of the Cd79a gene were replaced with a cDNA encoding a mammalian codon-optimized cre (hCre) followed by an SV40 poly(A) signal. Exon 1 was truncated to remove the Cd79a ATG start codon, and a tk-neo cassette flanked by FRT sites was introduced 3' to hCre. The neo cassette was deleted in chimeras by crossing to Flpe deleter mice. (J:113645, J:135783)
Generation of the floxed Atmintm1.2Jhh allele
 Tissue activity of this recombinase allele
Driver: Cd79a     Summary of all recombinase alleles driven by Cd79a.

View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd79a Mutation:  7 strains or lines available
Original:  J:113645 Hobeika E, et al., Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13789-94
All:  101 reference(s)

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MGI 6.04
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